HCID 13190190, compound → HCID 13190193, compound

Participants

Reaction Steps

A solution of 2.4 g of 11β,21-dihydroxy-16α,17α-methylenedioxy-1,4-pregnadiene-3,20-dione in 24 ml of pyridine and 12 ml of propionic acid anhydride is stirred for one hour at room temperature. After precipitation into ice water-sodium chloride, the mixture is filtered off and worked up as usual. The crude product is purified on 220 g of silica gel with a methylene chloride-acetone gradient (0-12% acetone), thus obtaining 2.5 g of 11β-hydroxy-16α,17α-methylenedioxy-21-propionyloxy-1,4-pregnadiene-3,20-dione, mp 184°-185° C.

Provenance & Evidence