HCID 13190202, compound → HCID 13190205, compound

Participants

Reaction Steps

18.0 g of 21-acetoxy-9α-fluoro-11β-hydroxy-16α,17α-methylenedioxy-1,4-pregnadiene-3,20-dione is stirred in a mixture of 216 ml of 60% perchloric acid and 720 ml of methanol at room temperature for 18 hours. The reaction solution is diluted with methylene chloride and poured on water. After extraction with methylene chloride, neutralizing, washing, drying, and concentration of the organic extracts, 14.0 g of a crude product is obtained which is recrystallized from hexane/acetone, yielding 10.6 g of 9α-fluoro-11β,21-dihydroxy-16α,17α-methylenedioxy-1,4-pregnadiene-3,20-dione, mp 262° C.

Provenance & Evidence