反应详情

温度

25 °C

To a mixture of 8.2 g. of 3-methoxy-2-naphthoic acid, 5.2 g. of aminotetrazole, and 80 ml. of pyridine was added dropwise 6.4 ml. of thionyl chloride, maintaining the temperature below 70° C. After stirring for one hour, the mixture was cooled to 25° C. and evaporated to dryness. The residue was washed with dilute hydrochloric acid, then recrystallized from N,N-dimethylformamide, then dissolved in base, filtered, reprecipitated with dilute acid, filtered, washed with methanol, then recrystallized again from N,N-dimethylformamide to provide 3-methoxy-N-(tetrazol-5-yl)naphthalene-2-carboxamide (a type IV compound), m.p. 280°-283° C.

1. additionTo a mixture of 8.2 g
2. customevaporated to dryness
3. washThe residue was washed with dilute hydrochloric acid
4. customrecrystallized from N,N-dimethylformamide
5. dissolutiondissolved in base
6. filtrationfiltered
7. customreprecipitated
8. additionwith dilute acid
9. filtrationfiltered
10. washwashed with methanol
11. customrecrystallized again from N,N-dimethylformamide