反应详情

92 g of 2-chloromethyl 2,3-dihydro [4H] 1,4-benzodioxin are dissolved in 675 ml acetic acid. In this solution it is added a mixture of 500 ml acetic acid and 250 ml nitric acid while keeping the temperature below 20°. The mixture is kept at room temperature for 2 hours then heated at 90° for 1 hour. It is thereafter poured in water and extracted with methylene chloride. 102 g of the nitroderivative are obtained. It is in the form of yellow crystalls which melt at 60°-62°.

1. additionIn this solution it is added
2. customthe temperature below 20°
3. temperaturethen heated at 90° for 1 hour
4. extractionextracted with methylene chloride
5. custom102 g of the nitroderivative are obtained
6. custommelt at 60°-62°