1,4-Dichlorobutane → 2-(4-Chloro-1-butyl)-3(2H)-benz[d]isothiazolone 1,1-Dioxide

HRID 1388712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1388712
[S:1]1([C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:5](=[O:6])[NH:4]1)(=[O:3])=[O:2].[Na].[Cl:14][CH2:15][CH2:16][CH2:17][CH2:18]Cl>CN(C)C=O>[Cl:14][CH2:15][CH2:16][CH2:17][CH2:18][N:4]1[C:5](=[O:6])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[S:1]1(=[O:2])=[O:3]

Komponenten

4

Edukt 2

HCID 80591,4-DichlorobutaneHCID 24181110Benzosulfinide sodium; Garantose sodium

Produkt 1

HCID 132898002-(4-Chloro-1-butyl)-3(2H)-benz[d]isothiazolone 1,1-DioxideAusbeute 12,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Sodium saccharin (5.6 g, 0.027 mole) and 1,4-dichlorobutane (14.9 ml, 0.135 mole) were taken into 100 ml of dimethylformamide and heated on a steam bath for 4 hours. The reaction mixture was evaporated in vacuo to an oil and the oil extracted with 100 ml of hexane. Residual hexane was removed from the remaining oil by vacuum evaporation to yield the title product (956 mg).

Aufarbeitung

  1. temperatureheated on a steam bath for 4 hours
  2. customThe reaction mixture was evaporated in vacuo to an oil
  3. extractionthe oil extracted with 100 ml of hexane
  4. customResidual hexane was removed from the remaining oil by vacuum evaporation

Quellen und Nachweise

ORD-Eintrag
ord-48ddd531a1e94276bbcfc3b2774e6749
Quelldatensatz
uspto-grants-1984_02
Patentnummer
US04432978

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