Methyl iodide → HCID 13064197, compound

HRID 1388722Notes

Reaction equation

HRID 1388722 reaction equation
[NH2:1][C:2]1[CH:6]([CH3:7])[CH2:5][N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:3]=1.[CH3:14][I:15]>>[I-:15].[NH2:1][C:2]1[CH:6]([CH3:7])[CH2:5][N+:4]([CH3:14])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 15580664HCID 15580664, compound

Product 1

HCID 13064197HCID 13064197, compound

Procedure

A 6.0 g. amount of 3-amino-4-methyl-1-phenyl-2-pyrazoline (Example 4) and 12.0 ml. of methyl iodide is heated at reflux for 2 hours. The reaction mixture is cooled and filtered to collect 11.2 g. of crude product. The material is dissolved in water and recrystallized from 95% ethanol to give 4.5 g. of the product of the Example as colorless needles, m.p. 168.5°-170° C.

Workup

  1. temperatureat reflux for 2 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. customto collect 11.2 g
  5. dissolutionThe material is dissolved in water
  6. customrecrystallized from 95% ethanol
  7. customto give 4.5 g

Sources & evidence

ORD record
ord-6d8a0f27e7814826a6e69d468bb5495e
Source dataset
uspto-grants-1984_02
Patent number
US04432991

Reaction notes

Loading…