HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-[3-(4-methylphenyl)propyl]-2-(2-benzofuranyl)-2-hydroxyethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Amino-1-(1-benzofuran-2-yl)ethan-1-ol | HCID 12814357 | — |
| Reactant | 3-(4-Methylphenyl)propyl 4-methylbenzene-1-sulfonate | HCID 53903301 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-[3-(4-methylphenyl)propyl]-2-(2-benzofuranyl)-2-hydroxyethanamine | HCID 12816509 | — |
Reaction Steps
A mixture of 2-(2-benzofuranyl)-2-hydroxyethanamine (1.75 g), 3-(4-methylphenyl)-1-(4-methylphenylsulphonyloxy) propane (3.0 g) and triethylamine (1.5 g) was stirred in dimethylsulphoxide for 2 days at ambient temperature. The mixture was poured into water, extracted with ether and the ether layers dried. Removal of the solvent gave an oil which was crystallised and recrystallised from ether to give N-[3-(4-methylphenyl)propyl]-2-(2-benzofuranyl)-2-hydroxyethanamine m.p. 118°-119°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04432993 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-d2a087c8d85f4801a77085a20c21022e |
| Source note | uspto-grants-1984_02 |