HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-[2-(4-Benzyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Benzyloxyphenylacetone | HCID 561253 | — |
| Reactant | 2-Amino-1-(1-benzofuran-2-yl)ethan-1-ol | HCID 12814357 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[2-(4-Benzyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine | HCID 12816511 | — |
Reaction Steps
This was prepared in an identical manner to the compound described in Example 2 using 2-(2-benzofuranyl)-2-hydroxyethanamine (3.51 g) and 1-(4-benzyloxyphenyl)propan-2-one (4.75 g). Chromatography of the residual oily solid on Kieselgel 60 (4% methanol in dichloromethane) gave the title compound, m.p. 111°-122°, as a 20:80 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04432993 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-760d555e632147a292fcb0c96d6b567f |
| Source note | uspto-grants-1984_02 |