HCID 131713403, compound → HCID 54536247, compound

Participants

Reaction Steps

A solution of the ester product from part (b) (1.42 g., 3.1 mmole) in 60 ml. of methanol is treated with 10% palladium-carbon catalyst (350 mg.) and hydrogenated in a Parr apparatus at an initial pressure of 45 psi. for 1.5 hours. The mixture is filtered through Celite and evaporated to dryness to give 1-[N-[ethoxy(phenylmethyl)phosphinyl]-L-alanyl]-L-proline as a colorless foam. Tlc (10% methanoldichloromethane) shows a single spot at Rf 0.31.

Provenance & Evidence