HCID 131713405, compound → HCID 53948448, compound

Participants

Reaction Steps

A mixture of the diester product from part (d) (2.0 g., 4 mmole), 10% palladium-carbon catalyst (350 mg.) and methanol (40 ml.) is hydrogenated in a Parr apparatus at 50 psi. for 1 hour. The catalyst is removed by filtration through a Celite bed and the filtrate evaporated to give 1-[N-[ethoxy(4-phenylbutyl)phosphinyl]-N-methylglycyl]-L-proline as a foam. Tlc (methanol/acetic acid/dichloromethane; 5:5:100) shows a major spot at Rf 0.6.

Provenance & Evidence