反应详情

24.6 g of ethyl α-(p-prenylphenyl)propionate was dissolved in 250 ml of ethanol, and a solution composed of 6.0 g of sodium hydroxide and 10 ml of water was added. The mixture was stirred overnight at room temperature, and concentrated. Water was added, and the mixtue was washed with diethyl ether. The resulting aqueous layer was acidified with 1 N hydrochloric acid, and extracted with diethyl ether. The extract was washed with an aqueous solution of sodium chloride, dried, concentrated and distilled to give 19.5 g of α-(p-prenylphenyl)propionic acid having the following boiling point and NMR spectrum.

1. additionwas added
2. concentrationconcentrated
3. additionWater was added
4. washthe mixtue was washed with diethyl ether
5. extractionextracted with diethyl ether
6. washThe extract was washed with an aqueous solution of sodium chloride
7. customdried
8. concentrationconcentrated
9. distillationdistilled