Dimethylformamide → HCID 70509339, compound

Participants

Reaction Steps

A mixture of 5 g of 1-amidino-4-piperidinepropionic acid hydrochloride, 3.23 g of methyl p-hydroxybenzoate, 4.38 g of dicyclohexylcarbodiimide, 100 ml of dry dimethylformamide and 20 ml of dry pyridine was stirred at room temperature for 24 hours, and the mixture was treated in the same procedure as in Example 11. The crystals obtained were recrystallized from isopropanolether to obtain 5.7 g (yield: 72.7%) of p-methoxycarbonylphenyl 1-amidino-4-piperidinepropionate hydrochloride as colorless needles having a melting point of 163° to 164.5° C.

Provenance & Evidence