(+-)-2-Mercaptopropionic acid → KM 1146

Participants

Reaction Steps

A mixture of 16.6 g of 2,4-dimethoxybenzaldehyde, 10.6 g of 2-mercaptopropionic acid and 6 g of ammonium carbonate in 250 ml of benzene was refluxed for 3 hours in a reaction vessel provided with a Dean-Stark apparatus at 80° C. while removing the distilled water. The crystals which separated out after cooling the reaction mixture were collected by filtration and recrystallized from hot benzene to obtain the object, colourless leaf-like crystals melting at 151° to 152.5° C. in an amount of 20.4 g corresponding to a yield of 81%.

Provenance & Evidence