Chloroform → 8-Chloro-6,11-dihydro-5H-dibenz[b,e]azepine

Participants

Reaction Steps

To a suspension of 1.5 g lithium aluminium hydride in 100 ml tetrahydrofuran is added with ice cooling first 1.05 ml chloroform and thereafter portionwise 3.0 g of 8-chloro-5,6-dihydro-11H-dibenz[b,e]azepin-6-one. The mixture is stirred at room temperature for 15 hours. To the mixture is then added dropwise under ice cooling 9.0 ml of a saturated solution of potassium carbonate. The precipitate is filtered off and washed with ether. The filtrate is then evaporated and the residue recrystallised from methylene chloride/ether/petroleum ether to give the heading compound, m.p. 132°-135°.

Provenance & Evidence