HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | N-Methyl-N-nitrosourea | HCID 12699 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 3-ethoxycarbonyl-4-hydroxy-1-methylpyrrole-2-acetate | HCID 13345719 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate | HCID 20469092 | — |
Reaction Steps
Ethyl 4-hydroxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate (20 mmole) is dissolved in 10 μl of diethyl ether containing diazomethane freshly prepared from N-methyl-N-nitrosourea and potassium hydroxide. After the reaction is allowed to stand at room temperature for about 0.5 hour, the ether is evaporated under reduced pressure at mild temperature and the residue, i.e., crude ethyl-4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate, is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04434175 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-195bafe7bb434b3881f51fa3bf30cad8 |
| Source note | uspto-grants-1984_02 |