1-Methylpyrrole → HCID 11040770, compound

Participants

Reaction Conditions

Reaction Steps

Under nitrogen atmosphere, to a mixture of 25.08 g of KSCN (0.125 mole) in 60 ml dry methanol chilled to -78° C. was added dropwise 20 g of Br2 (in 40 ml methanol). The resulting yellow solution was stirred for 5-10 minutes and 10.1 g (0.125 mole) of the 1-methylpyrrole added in one portion. The mixture was allowed to warm to ambient temperature and stirred for one hour. The mixture was poured into 600 ml of ice-water, extracted 2 times with 300 ml CH2Cl2. The CH2Cl2 extract was dried and concentrated to 16.1 g (90% yield) of 1-methyl-5-cyanothiopyrrole.

Provenance & Evidence