Dimethylformamide → (E)-1-(4-chlorophenyl)-1-cyclopropyl-N-[(2,4-difluoro-3-phenylphenyl)methoxy]methanimine

Participants

Reaction Steps

In a manner similar to Example 2, the reaction of 0.59 g (0.003 mole) of (E)-(4-chlorophenyl)(cyclopropyl)methanone oxime with 0.072 g (0.003 mole) of sodium hydride and 0.72 g (0.003 mole) of 3-chloromethyl-2,6-difluoro[1,1'-biphenyl] in 25 ml of a 20% solution of N,N-dimethylformamide in toluene produced (E)-(4-chlorophenyl)(cyclopropyl)methanone O-[(2,6-difluoro[1,1'-biphenyl]-3-yl)methyl]oxime as an oil.

Provenance & Evidence