HCID 70559509, compound → HCID 70560654, compound

HRID 1388966Notes

Reaction equation

HRID 1388966 reaction equation
[NH2:1][C@H:2]([C:10]([NH:12][CH2:13][C:14]([N:16]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=1[C:25](=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:17])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[ClH:24].[NH2:1][C@H:2]([C:10]([NH:12][CH2:13][C:14]([N:16]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=1[C:25](=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:17])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 70559509HCID 70559509, compound2×

Product 1

HCID 70560654HCID 70560654, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The foregoing free base was converted into the hydrochloride as follows: 4.5 g of L-phenylalanyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide were dissolved in a minimum volume of methanol at room temperature and treated, by titration, with an exact equivalent of 1-N-hydrochloric acid. The solvent was removed from the resulting solution by evaporation in vacuo at room temperature and finally by lyophilisation to give, in quantitative yield, L-phenylalanyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide hydrochloride as a hygroscopic white light-sensitive amorphous powder of melting point 130°-150° C. (slow decomposition); [α] D 20=+41.7° (c=1 in water).

Workup

  1. customThe solvent was removed from the resulting solution by evaporation in vacuo at room temperature and finally by lyophilisation

Sources & evidence

ORD record
ord-79df7ef923d04f9c843ceff511da626b
Source dataset
uspto-grants-1981_01
Patent number
USRE030473

Reaction notes

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