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Acetic Anhydride → 7-(1-ethyl-2-methyl-3-indolyl)-7-(diphenylamino)furo[3,4-b]pyrazine-5(7H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Diphenylamine | HCID 11487 | — |
| 反応物 | (1-Ethyl-2-methylindol-3-yl)-(2-carboxypyrazin-3-yl)ketone | HCID 20534320 | — |
| 生成物 | 7-(1-ethyl-2-methyl-3-indolyl)-7-(diphenylamino)furo[3,4-b]pyrazine-5(7H)-one | HCID 20534277 | — |
反応手順
A mixture containing 4 g. of 3-[(1-ethyl-2-methyl-3-indolyl)carbonyl]-2-pyrazinecarboxylic acid, 1.7 g. of diphenylamine and 15 ml. of acetic anhydride was stirred 1 hour at room temperature and then 30 minutes with gentle warming. The product, 7-(1-ethyl-2-methyl-3-indolyl)-7-(diphenylamino)furo[3,4-b]pyrazine-5(7H)-one was isolated by column chromatography as a red solid, m.p. 98°-100° C. A toluene solution of this product contacted with acidic clay or phenolic resin developed an orange image.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04243250 |
| 出典データセット | uspto-grants-1981_01 |
| ORD ID | ord-056e5670ee2d48c6b891e2cd1bf413b9 |
| 出典メモ | uspto-grants-1981_01 |