Dimethylcarbamoyl Chloride → HCID 20297540, compound

Participants

Reaction Steps

8.0 g (0.037 mol) of 5-(3-aminophenyl)-3-butyl-1,2,4-oxadiazole were dissolved in 15 ml pyridine and were reacted with 3.4 ml (0.037 mol) of dimethylcarbamoylchloride. The reaction was complete after stirring for 8 hours at room temperature. The mass was then reacted with about 100 ml ice water resulting in precipitation of the reaction product. The reaction produce was removed by suction, subjected to drying at 50° C. in a vacuum and recrystallized from diisopropylether. There were obtained 8.3 g=77.5% of the theoretical value of 3-butyl-5-[3-(3,3-dimethylureido)-phenyl]-1,2,4-oxadiazole; m.p. 108° to 110° C.

Provenance & Evidence