HCID 54104092, compound → Ethyl 5-(4-chlorophenyl)-1,2-oxazole-4-carboxylate

HRID 1389007Notes

Reaction equation

HRID 1389007 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[C:5]([C:10](=[O:18])[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=[CH:6][N:7](C)C)[CH3:2].C(OC(=O)C(C(=O)C1C=CC=CC=1)=CN(C)C)C>>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[N:7][O:18][C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=[O:19])[CH3:2]

Participants

3

Reactant 2

HCID 54104092HCID 54104092, compoundHCID 54499154Ethyl-2-benzoyl-3-dimethylaminopropenoate

Product 1

HCID 20148334Ethyl 5-(4-chlorophenyl)-1,2-oxazole-4-carboxylateYield 49%

Procedure

The procedure of Example 15 was employed utilizing ethyl-2-(4'-chlorobenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-benzoyl-3-dimethylaminopropenoate to yield ethyl-5-(4'-chlorophenyl)-4-isoxazolecarboxylate (3.7 g.; 49% yield) having a melting point of 58°-60° C. and the following analysis:

Sources & evidence

ORD record
ord-76a3b04e0c0c483dbe65173f09e15d24
Source dataset
uspto-grants-1981_01
Patent number
US04243406

Reaction notes

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