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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1389008Generated: October 26, 2026

Ethyl-2-(4-toluyl)-3-dimethylaminopropenoate → Ethyl 5-(p-tolyl)isoxazole-4-carboxylate

https://huagongshe.com/reaction/1389008

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl-2-(4-toluyl)-3-dimethylaminopropenoateHCID 54008809—
ReactantEthyl-2-benzoyl-3-dimethylaminopropenoateHCID 54499154—
ProductEthyl 5-(p-tolyl)isoxazole-4-carboxylateHCID 2222099959%

Reaction Steps

The procedure of Example 15 was employed utilizing ethyl-2-(4-toluyl)-3-dimethylaminopropenoate in lieu of ethyl-2-benzoyl-3-dimethylaminopropenoate to yield ethyl-5-(4'-methylphenyl)-4-isoxazolecarboxylate (2.03 g.; 59% yield) having a melting point of 42°-44° C. and the following analysis:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04243406
Source datasetuspto-grants-1981_01
ORD IDord-4ec352fa59dd41738e872006d4cc8cd2
Source noteuspto-grants-1981_01