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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1389013Generated: October 30, 2026

Ethyl-2-(2'-methylbenzoyl)-3-dimethylaminopropenoate → 5-o-Tolylisoxazole-4-carboxylic acid ethyl ester

https://huagongshe.com/reaction/1389013

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl-2-(2'-methylbenzoyl)-3-dimethylaminopropenoateHCID 54457205—
ReactantEthyl 2-(2-chlorobenzoyl)-3-dimethylaminopropenoateHCID 54509863—
Product5-o-Tolylisoxazole-4-carboxylic acid ethyl esterHCID 2029750082.6%

Reaction Steps

The procedure of Example 22 was employed utilizing ethyl-2-(2'-methylbenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-(2'-chlorobenzoyl)-3-dimethylaminopropenoate to yield ethyl-5-(2'-methylphenyl)-4-isoxazolecarboxylate (1.9 g.; 82.6% yield) as an oil having the following analysis:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04243406
Source datasetuspto-grants-1981_01
ORD IDord-7d66720156854f54b3d920107ebd130a
Source noteuspto-grants-1981_01