HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1389014Generated: October 29, 2026
1,4-Dioxane → Ethyl 5-(2-(trifluoromethyl)phenyl)isoxazole-4-carboxylate
https://huagongshe.com/reaction/1389014
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 3-Dimethylamino-2-(2-trifluoromethyl-benzoyl)-acrylic acid ethyl ester | HCID 54042795 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 5-(2-(trifluoromethyl)phenyl)isoxazole-4-carboxylate | HCID 20297498 | 56.2% |
Reaction Steps
Ethyl-2-(2'-trifluoromethylbenzoyl)-3-dimethylaminopropenoate (3.14 g.; 0.01 mol.) was dissolved in 15 ml. of dioxane. To this solution was added a solution of hydroxylamine hydrochloride (1.05 g.; 0.015 mol.) in 5 ml. of water. The resulting solution was stirred for 14 hours at 25° C. Extraction with water and diethyl ether yielded ethyl-5-(2'-trifluoromethylphenyl)-4-isoxazolecarboxylate as an oil (1.6 g.; 56.2% yield) having the following analysis:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04243406 |
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| Source dataset | uspto-grants-1981_01 |
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| ORD ID | ord-ffce516bdfa54b64a150943b113198d7 |
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| Source note | uspto-grants-1981_01 |
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