HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-phenyl-1,2-oxazole-4-carboxylate → 5-Phenylisoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-phenyl-1,2-oxazole-4-carboxylate | HCID 11481356 | — |
| Reactant | Ethyl-5-(2',4'-dichlorophenyl)-4-isoxazolecarboxylate | HCID 22221209 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Phenylisoxazole-4-carboxylic acid | HCID 14787253 | 55% |
Reaction Steps
The procedure of Example 27 was employed utilizing ethyl-5-phenyl-4-isoxazolecarboxylate in lieu of ethyl-5-(2',4'-dichlorophenyl)-4-isoxazolecarboxylate to yield upon recrystallization with toluene, 5-phenyl-4-isoxazolecarboxylic acid (7.5 g.; 55% yield) as a white solid having a melting point of 153°-154° C. and the following analysis:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243406 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-c13afc80eebd4a2c823485234fbcbcb1 |
| Source note | uspto-grants-1981_01 |