Ammonia → HCID 20297955, compound

HRID 1389037Notes

Reaction equation

HRID 1389037 reaction equation
[CH2:1]([N:3]([CH2:14][CH3:15])[C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[CH2:7][CH2:8][C:9]#N)[CH3:2].[OH-:16].[Na+].N.[OH2:19]>>[CH2:1]([N:3]([CH2:14][CH3:15])[C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[CH2:7][CH2:8][C:9]([OH:19])=[O:16])[CH3:2]

Participants

5

Reactant 4

HCID 222Ammonia2×HCID 962WaterHCID 14798Sodium HydroxideHCID 202979473-[3-(Diethylamino)phenyl]propanenitrile

Product 1

HCID 20297955HCID 20297955, compound

Procedure

A mixture of 60.6 parts of 3-diethylamino-hydrocinnamonitrile, 250 parts by volume of methylated spirits of denatured alcohol, 100 parts of water and 60 parts by volume of a 35° Be solution of sodium hydroxide was heated under reflux until the evolution of ammonia ceased. After the evolution of ammonia had stopped, the mixture was cooled and then neutralized by addition of 19° Be hydrochloric acid. After filtering and drying, 3-diethylamino-hydrocinnamic acid was obtained of the formula:

Workup

  1. temperaturewas heated
  2. temperaturethe mixture was cooled
  3. filtrationAfter filtering
  4. customdrying

Sources & evidence

ORD record
ord-5d1d1314b5084b60b98e18400c3fa9de
Source dataset
uspto-grants-1981_01
Patent number
US04243606

Reaction notes

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