Bifonazole → HCID 86737425, compound

Participants

Reaction Conditions

Reaction Steps

15.1 g (0.05 mol) of 1-[α-(4-biphenylyl)-benzyl]-imidazole and 15.2 g (0.05 mol) of 2-chlorophenyl-diphenylmethyl chloride are suspended in 400 ml of acetonitrile and the suspension is heated to 80° C. for 24 hours. It is then filtered and the filtrate is concentrated by distilling off the solvent. The residue crystallises after trituration with ether. 13 g (42% of theory) of 1-[α-(4-biphenylyl)-benzyl]-3-(2-chlorophenyl-diphenyl-methyl)-imidazolium chloride of melting point 140° C. (with decomposition) are obtained.

Provenance & Evidence