HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Fluoro-4-(hexadecylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 3-fluoro-4-(hexadecylamino)benzoate | HCID 20536470 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Fluoro-4-(hexadecylamino)benzoic acid | HCID 20536410 | — |
Reaction Steps
A solution of 3.8 g of potassium hydroxide in 15 ml of water is added to a mixture of 3.5 g of ethyl 3-fluoro-4-hexadecylaminobenzoate, 30 ml of water and 30 ml of ethanol. Upon heating, a clear solution is formed and after 20 hours, the hot solution is acidified with concentrated hydrochloric acid and cooled. The precipitate is collected and recrystallized from ethanol and then from chloroform to yield 3-fluoro-4-(hexadecylamino)benzoic acid as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243609 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-0a2ad3191c054eb68b80a13be2dee608 |
| Source note | uspto-grants-1981_01 |