HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1-(Methoxycarbonyl)propyl 3-fluoro-4-(hexadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl 2-hydroxybutanoate | HCID 520445 | — |
| Reactant | 3-Fluoro-4-hexadecylaminobenzoyl chloride hydrochloride | HCID 20536440 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Methoxycarbonyl)propyl 3-fluoro-4-(hexadecylamino)benzoate | HCID 20536481 | — |
Reaction Steps
To a solution of 10.0 g 3-fluoro-4-(hexadecylamino)-benzoyl chloride hydrochloride in 200 ml methylene chloride is added dropwise a solution of 3 g. methyl α-hydroxybutyrate and 5 g triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several portions of ether. The ether solution is washed with water, dried and evaporated to yield 1-(methoxycarbonyl)propyl 3-fluoro-4-(hexadecylamino)benzoate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243609 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-8aa8c122dc194730906bebafe7255833 |
| Source note | uspto-grants-1981_01 |