HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 3-fluoro-4-(hexadecylamino)benzoylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Tert-butyl ethyl 3-fluoro-4-(hexadecylamino)benzoylmalonate | HCID 53991576 | — |
| Product | Ethyl 3-fluoro-4-(hexadecylamino)benzoylacetate | HCID 20536531 | — |
Reaction Steps
A solution of 3.0 g. of tert-butyl ethyl 3-fluoro-4-(hexadecylamino)benzoylmalonate 10 ml of trifluoroacetic acid is warmed with stirring for 3 hours. The solution is poured onto ice and neutralized with potassium hydroxide. The resulting precipitate is collected by filtration, washed with water and dried. Recrystallization from chloroform affords ethyl 3-fluoro-4-(hexadecylamino)benzoylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243609 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-bd9f801642eb45c6b1eb2121e447b1aa |
| Source note | uspto-grants-1981_01 |