HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Amino-3-fluorobenzenepropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(3-Fluoro-4-nitrophenyl)-2-propenoic acid | HCID 54267338 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Ethanol | HCID 702 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 4-Amino-3-fluorobenzenepropanoic acid | HCID 20536463 | — |
Reaction Steps
A mixture of 5.0 g. of 3-fluoro-4-nitrocinnamic acid and 100 mg. of 10% palladium-on-carbon in 200 ml. of ethanol containing 5 drops of 5.5 N ethanolic hydrogen chloride is treated with hydrogen in a Parr apparatus at room temperature for 3 hours. The mixture is then filtered through Celite and the filtrate is concentrated, affording 3-fluoro-4-aminohydrocinnamic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243609 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-fbc5edd3bbd446debaf8715dd50c9ad6 |
| Source note | uspto-grants-1981_01 |