HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron trifluoride etherate → HCID 20536450, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Amino-3-fluorobenzenepropanoic acid | HCID 20536463 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20536450 | HCID 20536450 | — |
Reaction Steps
A solution of 3-fluoro-4-aminohydrocinnamic acid in 100 ml. of absolute ethanol containing 16 ml. of boron trifluoride etherate is heated to reflux for 48 hours. The solution is then cooled, poured into 5% aqueous sodium carbonate and extracted with methylene chloride. Evaporation of the organic extracts yields ethyl 3-fluoro-4-aminohydrocinnamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243609 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-d81255f5767e445abc8421aaba398f1a |
| Source note | uspto-grants-1981_01 |