Sodium Hydroxide → HCID 20298261, compound

HRID 1389122Notes

Reaction equation

HRID 1389122 reaction equation
C([O:3][C:4](=[O:14])[C:5]([C:7]1[NH:8][C:9]([CH2:12][CH3:13])=[CH:10][CH:11]=1)=[O:6])C.[OH-].[Na+]>O>[CH2:12]([C:9]1[NH:8][C:7]([C:5](=[O:6])[C:4]([OH:14])=[O:3])=[CH:11][CH:10]=1)[CH3:13]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54286409HCID 54286409, compound

Product 1

HCID 20298261HCID 20298261, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5-ethyl-2-pyrrolylglyoxylic acid ethyl ester (1.95 g.) and sodium hydroxide (0.44 g.) in water (25 ml.) was heated on a steam bath for 1.5 hours. The mixture was cooled, filtered and the filtrate was acidified with 2 N hydrochloric acid. The solid was filtered off, washed with a little water, dried and crystallized from toluene to give 5-ethyl-2-pyrrolylglyoxylic acid (1.40 g.), M.P. 126°-128°). Found: C, 57.55; H, 5.53; N, 8.70. C8H9NO3 requires: C, 57.48; H, 5.43; N, 8.38%.

Workup

  1. temperaturewas heated on a steam bath for 1.5 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. filtrationThe solid was filtered off
  5. washwashed with a little water
  6. customdried
  7. customcrystallized from toluene

Sources & evidence

ORD record
ord-dcd6b97cc16741048cd2ad6c4169cb37
Source dataset
uspto-grants-1981_01
Patent number
US04243672

Reaction notes

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