Sodium Hydroxide → HCID 23664913, compound

HRID 1389123Notes

Reaction equation

HRID 1389123 reaction equation
C([O:3][C:4](=[O:16])[C:5]([C:7]1[NH:8][C:9]([CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:10][CH:11]=1)=[O:6])C.[OH-].[Na+:18]>O>[OH2:3].[Na+:18].[CH:13]1([CH2:12][C:9]2[NH:8][C:7]([C:5](=[O:6])[C:4]([O-:16])=[O:3])=[CH:11][CH:10]=2)[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53640952HCID 53640952, compound

Product 1

HCID 23664913HCID 23664913, compoundYield 94.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5-cyclopropylmethyl-2-pyrrolylglyoxylic acid ethyl ester (6.63 g.) and sodium hydroxide (1.32 g.) was heated in water (40 ml.) as described in Example 20. The resulting solution was cooled to 5° and the solid was filtered off and crystallized from acetone to give 5-cyclopropylmethyl-2-pyrrolylglyoxylic acid sodium salt hydrate (3.3 g.), M.P. 228°-232°. Found: C, 51.50; H, 5.19; N, 5.91. C10H10NO3Na. H2O requires: C, 51.50; H, 5.19; N, 6.01%.

Workup

  1. temperatureThe resulting solution was cooled to 5°
  2. filtrationthe solid was filtered off
  3. customcrystallized from acetone

Sources & evidence

ORD record
ord-cb633702e3174c7c8e0c114139b38cc9
Source dataset
uspto-grants-1981_01
Patent number
US04243672

Reaction notes

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