HCID 70574310, compound → HCID 9859690, compound

Participants

Reaction Steps

4-(4-Fluoro-6-methoxy-2-naphthyl)-4-hydroxy-but-3-en-2-one (3 g) was hydrogenated at atmospheric pressure and room temperature in glacial acetic acid (150 ml) using 10% palladium on carbon (0.5 g) catalyst. When hydrogen uptake had ceased the catalyst was removed by filtration and the filtrate concentrated. The residue was taken up in ether and the resulting solution washed with sodium bicarbonate solution, then water, dried (MgSO4) and concentrated in vacuo to give a low melting solid which was recrystallised from ether to give colourless crystals (1.40 g) m.p. 69°-70° C. 'H Nmr (CDCl3)δ: 6.81-7.71 (m, 5H), 3.89 (s, 3H), 2.88-2.99 (m, 4H), 2.12 (s, 3H).

Provenance & Evidence