Hydrochloric Acid → HCID 20298531, compound

Participants

Reaction Steps

The ester (9 g) was dissolved in methanol (180 ml) and 10% aqueous sodium hydroxide solution (90 ml) was added. The solution was heated under reflux for 2 hours. It was then poured into water (270 ml) and the suspension was acidified with dilute hydrochloric acid. The precipitate produced was extracted into ethyl acetate. The organic solution was dried over anhydrous sodium sulphate and the solvent was removed under reduced pressure to give 3-(4-fluoro-6-methoxy-2-naphthyl)butanoic acid as an oil which crystallised on standing (12.4 g., >100%).

Provenance & Evidence