Triethylamine → 4-amino-6,7-dimethoxy-2-[4-(N-n-butylcarbamoyl)piperidino]quinazoline hydrochloride

Participants

Reaction Steps

4-Amino-2-chloro-6,7-dimethoxyquinazoline (1.2 g), 4-(N-n-butylcarbamoyl)piperidine (1.01 g) and triethylamine (2.52 g) in n-butanol (105 ml) were heated under reflux for 24 hours. The mixture was then cooled, the solvent evaporated in vacuo, and the resultant solid shaken with chloroform and water. The solid product was collected by filtration, and recrystallised twice from ethanol to give 4-amino-6,7-dimethoxy-2-[4-(N-n-butylcarbamoyl)piperidino]quinazoline hydrochloride (0.57 g), m.p. 263°-264°.

Provenance & Evidence