1,2,3,4-Tetrahydroisoquinoline → HCID 883945, compound

HRID 1389155Notes

Reaction equation

HRID 1389155 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17](Cl)=[O:18])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][NH:21]1>>[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][N:21]1[C:17]([CH:14]1[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]1)=[O:18]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 2776270Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate

Product 1

HCID 883945HCID 883945, compound

Procedure

This compound was prepared similarly to Preparation C, starting from 1-benzyloxycarbonylpiperidine-4-carboxylic acid chloride and 1,2,3,4-tetrahydroisoquinoline, and was used directly in Example 13. This intermediate was characterised as the hydrochloride salt, m.p. 245°-247°.

Workup

  1. customThis compound was prepared similarly to Preparation C

Sources & evidence

ORD record
ord-43763f0504b64c4182fbc36cefa6e761
Source dataset
uspto-grants-1981_01
Patent number
US04243666

Reaction notes

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