HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → N-(2-Hydroxyethyl)piperidine-4-carboximidic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate | HCID 2776270 | — |
| Reactant | HCID 20298124 | HCID 20298124 | — |
| Product | N-(2-Hydroxyethyl)piperidine-4-carboximidic acid | HCID 2760458 | — |
Reaction Steps
1-Benzyloxycarbonyl-4-[N-(2-hydroxyethyl)carbamoyl]piperidine [6.24 g, m.p. 107°-108°, Found: C, 62.8; H, 7.2; N, 9.0; Calculated: C, 62.7; H, 7.2; N, 9.1; prepared similarly to Preparation C but starting from 1-benzyloxycarbonylpiperidine-4-carboxylic acid chloride and 2-hydroxyethylamine] was hydrogenated as in Preparation G to give 4-[N-(2-hydroxyethyl)carbamoyl]piperidine. The i.r. and n.m.r. spectra were consistent with this structure and the product was used in Example 6 without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243666 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-800214de9e04481aa92ee7ff57d0c805 |
| Source note | uspto-grants-1981_01 |