4-Piperidinecarboxylic acid → HCID 20298107, compound

HRID 1389158Notes

Reaction equation

HRID 1389158 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4](Cl)[N:3]=1.[C:17]([CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)([OH:19])=[O:18]>>[OH2:12].[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([N:23]2[CH2:24][CH2:25][CH:20]([C:17]([OH:19])=[O:18])[CH2:21][CH2:22]2)[N:3]=1

Participants

3

Reactant 2

HCID 37734-Piperidinecarboxylic acidHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamine

Product 1

HCID 20298107HCID 20298107, compound

Procedure

The above was prepared similarly to Example 1, starting from 4-amino-2-chloro-6,7-dimethoxyquinazoline and 4-carboxypiperidine and had an m.p. of 295°.

Workup

  1. customThe above was prepared similarly to Example 1

Sources & evidence

ORD record
ord-f622b3944db94e71a4f0f1469390cbe6
Source dataset
uspto-grants-1981_01
Patent number
US04243666

Reaction notes

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