1-Butanol → Acetate

Participants

Reaction Steps

4-Amino-2-chloro-6,7-dimethoxyquinazoline (4.8 g), 2-(piperidin-4-oxy)phenylacetic acid hydrochloride (4.9 g) and triethylamine (5 ml) in n-butanol (100 ml) were heated under reflux for 20 hours. The mixture was cooled, and the precipitated solid was collected and washed with ether. A sample of this solid (0.7 g) was recrystallised from acetic acid, and the resulting solid washed with ether to give 4-amino-2-[4-(1-carboxy-1-phenyl-methoxy)piperidino]-6,7-dimethoxyquinazoline, acetate (0.56 g), m.p. 271°-274°.

Provenance & Evidence