Epichlorohydrin → HCID 20298508, compound

HRID 1389169Notes

Reaction equation

HRID 1389169 reaction equation
[CH2:1]([CH:3]1[O:5][CH2:4]1)[Cl:2].[CH:6]([S:9][C:10]1[CH:11]=[C:12]([OH:16])[CH:13]=[CH:14][CH:15]=1)([CH3:8])[CH3:7].[CH2:17]([NH2:25])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>>[ClH:2].[CH3:7][CH:6]([S:9][C:10]1[CH:11]=[C:12]([CH:13]=[CH:14][CH:15]=1)[O:16][CH2:1][CH:3]([OH:5])[CH2:4][NH:25][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH3:8]

Participants

4

Reactant 3

HCID 7835EpichlorohydrinHCID 8143OctylamineHCID 20298519HCID 20298519, compound

Product 1

HCID 20298508HCID 20298508, compoundYield 13%

Procedure

Reaction of the epichlorohydrin derivative of 3-(isopropylthio)phenol (4.85 g., 0.029 mole) with n-octylamine (4 g., 0.031 mole) according to the procedure of Example 2(b) and crystallization of the crude product from ethanol-ether affords a 13% yield of analytically pure 1-[3-[(1-methylethyl)thio]phenoxy]-3-(octylamino)2-propanol hydrochloride, m.p. 125°-127° (corr.).

Workup

  1. customaccording to the procedure of Example 2(b) and crystallization of the crude product from ethanol-ether

Sources & evidence

ORD record
ord-4a11dcb80ab141748041589255b22a50
Source dataset
uspto-grants-1981_01
Patent number
US04243681

Reaction notes

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