反应详情

A solution of 3-(3-trifluoromethylphenyl)propionic acid (13.6 g) in anhydrous ethanol (25 ml) containing concentrated sulphuric acid (1.5 ml) was heated at reflux for 24 hours and was then poured into water (100 ml). The mixture was extracted with diethyl ether and the ethereal extract was washed with water, with aqueous sodium carbonate solution (2 N), and with water, then dried over magnesium sulphate and evaporated. The resulting residue was distilled, to give ethyl 3-(3-trifluoromethylphenyl)propionate (11.5 g) in the form of a colourless oil, b.p. 133°-135° C./17 mm Hg. [elemental analysis: C, 58.6; H, 5.2%. C12H13F3O2 requires C, 58.5; H, 5.3%. νmax 1125, 1170, 1330 and 1740 cm-1 ].

1. temperaturewas heated
2. temperatureat reflux for 24 hours
3. extractionThe mixture was extracted with diethyl ether
4. extractionthe ethereal extract
5. washwas washed with water, with aqueous sodium carbonate solution (2 N)
6. dry with materialwith water, then dried over magnesium sulphate
7. customevaporated
8. distillationThe resulting residue was distilled