3,5-Dimethoxybenzaldehyde → 3,5-Dimethoxy-beta-methylstyrene oxide

HRID 1389198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1389198
[C:1]1([SH+]C2C=CC=CC=2)C=CC=C[CH:2]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:21]=[C:22]([O:24][CH3:25])[CH:23]=1)[CH:19]=[O:20]>O1CCCC1>[CH3:25][O:24][C:22]1[CH:21]=[C:18]([CH:17]=[C:16]([O:15][CH3:14])[CH:23]=1)[CH:19]1[O:20][CH:1]1[CH3:2]

Komponenten

4

Edukt 2

HCID 817473,5-DimethoxybenzaldehydeHCID 22290449Diphenylsulfonium

Produkt 1

HCID 130604403,5-Dimethoxy-beta-methylstyrene oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

To a -78° C. solution of diphenylsulfonium ethylide (1.0 mole) in tetrahydrofuran (one liter) is slowly added 3,5-dimethoxybenzaldehyde (1.0 mole). The reaction mixture is stirred at -78° C. for 3 hours and then allowed to warm to room temperature. It is then added to ether-water and the ether phase separated. The ether phase is washed with water, dried (MgSO4) and evaporated. Fractional distillation of the residue gives the title product.

Aufarbeitung

  1. customTo a -78° C.
  2. temperatureto warm to room temperature
  3. customthe ether phase separated
  4. washThe ether phase is washed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. distillationFractional distillation of the residue

Quellen und Nachweise

ORD-Eintrag
ord-19bbe1511de84db9934d417171dd12d1
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04243674

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