Potassium Hydroxide → HCID 20298422, compound

Participants

Reaction Steps

15.0 g of ethyl 4-[p-chloro-N-(biphenyl-2-yl)benzamido]-butyrate is dissolved in 100 ml of benzene and, after the addition thereto of a solution of 2.8 g of potassium hydroxide in 20 ml of ethanol, is then stirred at room temperature for 5 hours. The solvent is then distilled off in vacuo, and the obtained residue is dissolved in water. The resulting aqueous solution is acidified with dilute hydrochloric acid, and the precipitate, which separates out, is taken up in methylene chloride. The residue remaining, after drying and distilling off the methylene chloride, is recrystallized from an ethanol/water mixture (2:1) to obtain 10.1 g (72.1% of theory) of 4-[p-chloro-N-(biphenyl-2-yl)benzamido]butyric acid, MP 135° to 137°.

Provenance & Evidence