HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoyl chloride → HCID 20298404, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 20298419 | HCID 20298419 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 20298404 | HCID 20298404 | 84.6% |
Reaction Steps
Analogously to Example 47b), 10.0 g of ethyl 4-(biphenyl-2-yl)aminobutyrate and 4.6 g of ethyldiisopropylamine in 50 ml of benzene are reacted with 5.6 g of p-fluorobenzoyl chloride. The reaction product is recrystallized from cyclohexane to obtain 12.1 g (84.6% of theory) of ethyl 4-[p-fluoro-N-(biphenyl-2-yl)-benzamido]butyrate, MP 83° to 84°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243678 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-1743638d301745ee94a9ae30d76544fb |
| Source note | uspto-grants-1981_01 |