HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetoxybenzoyl chloride → HCID 20298463, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetoxybenzoyl chloride | HCID 79668 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 20298423 | HCID 20298423 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 20298463 | HCID 20298463 | 73.5% |
Reaction Steps
15.0 g of ethyl 5-(biphenyl-2-yl)aminovalerate is reacted, analogously to Example 47b), with 6.6 g of ethyldiisopropylamine and 10.0 g of o-acetoxybenzoylchloride in 70 ml of benzene to obtain, as reaction product, 17.0 g (73.4% of theory) of ethyl 5-[o-acetoxy-N-(biphenyl-2-yl)-benzamido]valerate as a viscous non-distillable oil. The saponification of this ester yields 9.1 g (63.2% of theory) of 5-[o-hydroxy-N-(biphenyl-2-yl)benzamido]valeric acid, MP 138° to 139°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243678 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-b450b5fd7df44297890e7212de7103f5 |
| Source note | uspto-grants-1981_01 |