HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-methoxybenzoyl chloride → 4-[5-chloro-2-methoxy-N-(6-methoxybiphenyl-3-yl)benzamido]-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-methoxybenzoyl chloride | HCID 12384176 | — |
| Reactant | Ethyl 4-(6-methoxybiphenyl-3-yl)aminobutyrate | HCID 20298363 | — |
| Product | 4-[5-chloro-2-methoxy-N-(6-methoxybiphenyl-3-yl)benzamido]-butyric acid | HCID 20298336 | 70.1% |
Reaction Steps
Analogously to Example 59, reacting 7.0 g of ethyl 4-(6-methoxybiphenyl-3-yl)aminobutyrate with 4.6 g of 5-chloro-2-methoxybenzoyl chloride, followed by saponification of the intermediate product, yields 7.1 g (70.1% of theory) of 4-[5-chloro-2-methoxy-N-(6-methoxybiphenyl-3-yl)benzamido]-butyric acid, MP 155° to 156°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243678 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-8980ef1045c247dda8695d48cc47ee8f |
| Source note | uspto-grants-1981_01 |