Potassium Hydroxide → HCID 20298406, compound

Participants

Reaction Steps

A solution of 8.0 g of ethyl 5-(biphenyl-2-yl)amino-valerate (see Example 53) in 60 ml of benzene is mixed with a solution of 2.2 g of potassium hydroxide in 20 ml of ethanol. After allowing the resulting admixture to stand for 24 hours at room temperature, the solvent mixture is distilled off in vacuo. The residue is then dissolved in water; the obtained aqueous solution is washed with diethyl ether and then acidified with dilute hydrochloric acid. The formed precipitate, which is oily at first, is taken up in dichloromethane. The solvent is then distilled off and the residue recrystallized from ethyl acetate/petrol ether (1:1) to obtain 5.6 g (77.3% of theory) of 5-[N-(biphenyl-2-yl)amino]valeric acid, MP 73° to 75°.

Provenance & Evidence