Hydrochloric Acid → 4-(Phenoxymethyl)piperidine--hydrogen chloride (1/1)

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Reaction Steps

A mixture of 18.5 g (0.1 mole) of 4-phenoxymethylpyridine, 250 ml of methanol, 250 ml of 3 N methanolic hydrogen chloride solution and 2 g of platinum oxide is shaken at ambient temperature under a hydrogen pressure of 1 atmosphere absolute. After the take up of the calculated amount of hydrogen, the catalyst is filtered off, the filtrate is evaporated in a vacuum and the residue is recrystallized from ethanol. There are obtained 12.0 g of 4-phenoxymethylpiperidine hydrochloride (53% of theory); m.p. 218°-219° C. The free base is obtained by treating the hydrochloride with an aqueous solution of sodium hydroxide.

Provenance & Evidence